GoldMine CRM is a system developed by FrontRange Solutions. The biggest problem when running a CRM is doing your email marketing through it, GoldMine normally crashes at around 1000 emails if your ISP has not blocked you by then. Finding an email marketing service that syncs with GoldMine can be complicated and to tap into GM database is major task.
A company called Communicator Corps has developed an online email marketing system that can sync (bilaterally) with GoldMine CRM. Their system can update unsubscribers, generate reports, deliver 1.5 million email per hour plus all other common email marketing tasks.